Holders Manchester City will travel to West Ham in the Carabao Cup fourth round.
West Ham beat Manchester United in round three and will face their neighbours – who have won the past four EFL Cups – next.
Championship side Preston will host Liverpool at Deepdale, while Arsenal play Leeds and Chelsea host Southampton in two of five all-Premier League ties.
The games will be played in the week of 25 October.
Sunderland, the only League One club left, visit Championship side QPR.
Fourth-round draw in full
Chelsea v Southampton
Arsenal v Leeds
Stoke v Brentford
West Ham v Manchester City
Leicester v Brighton
Burnley v Tottenham
QPR v Sunderland
Preston v Liverpool