Defender Leah Williamson has been ruled out of England’s Women’s World Cup qualifiers this month because of “a significant” hamstring injury while her Arsenal team-mate Jordan Nobbs has been recalled to Sarina Wiegman’s squad.
Williamson faced Tottenham on Saturday but later “experienced discomfort”.
Gunners manager Jonas Eidevall said scans showed the injury may “possibly leave her out this whole year”.
The 24-year-old has captained England in every game since Wiegman took over.
In addition to missing games for her country, she would be absent for up to seven games for Arsenal if she is ruled out until 2022.
Her Gunners team-mate Nobbs has been called up by the Dutch manager for the first time, having previously been ruled out because of her own injury problems.
England face Austria at the Stadium of Light in Sunderland on Saturday, 27 November before taking on Latvia at Doncaster Rovers’ Keepmoat Stadium three days later.
The Lionesses are top of their group after four games, having scored 32 goals and conceded none so far.
England squad: Mary Earps, Hannah Hampton, Sandy MacIver, Millie Bright, Jess Carter, Niamh Charles, Rachel Daly, Alex Greenwood, Demi Stokes, Lotte Wubben-Moy, Jordan Nobbs, Jill Scott, Georgia Stanway, Keira Walsh, Katie Zelem, Bethany England, Lauren Hemp, Fran Kirby, Beth Mead, Nikita Parris, Alessia Russo, Ella Toone, Ellen White.
More to follow.