It’s Week 5! The 49ers have looked like the best team in football through four weeks, and now they will face their toughest test yet in a rematch of last season’s divisional round against the Cowboys. In a crucial AFC matchup, the Jaguars welcome the Bills to London as Jacksonville plays over there for the second straight week.
Meanwhile, the Texans, Colts and Jets are all underdogs, but each were picked to win by the majority of our staff.
Here’s who is picking games this season:
Albert Breer, senior NFL reporter
Conor Orr, senior writer
Gilberto Manzano, staff writer
Matt Verderame, staff writer
John Pluym, managing editor
Mitch Goldich, editor
Claire Kuwana, editor
All picks are straight up. Visit SI Betting for picks against the spread.
Red squares denote an upset.
